{"id":1394,"date":"2026-08-26T11:38:29","date_gmt":"2026-08-26T11:38:29","guid":{"rendered":"https:\/\/separcontenidos.es\/viaaerea\/?p=1394"},"modified":"2026-08-26T11:54:11","modified_gmt":"2026-08-26T11:54:11","slug":"1394","status":"publish","type":"post","link":"http:\/\/separcontenidos.es\/viaaerea\/archivos\/1394","title":{"rendered":"ASMA: Selecci\u00f3n de 10 art\u00edculos relevantes (julio 2026)"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-op38y-833d742866d026877f22cab014de4163\">\n.avia-image-container.av-op38y-833d742866d026877f22cab014de4163 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-op38y-833d742866d026877f22cab014de4163 av-styling- avia-align-center  avia-builder-el-0  el_before_av_hr  avia-builder-el-first '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img class='wp-image-1229 avia-img-lazy-loading-not-1229 avia_image' src='http:\/\/separcontenidos.es\/viaaerea\/wp-content\/uploads\/2026\/07\/Banners-web_01_enquadre-superior-2048x175.png' alt='' title='Banners web_01_enquadre superior'  height=\"175\" width=\"2048\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div>\n<div  class='hr av-l4hma-5f01f9223dcd929b962aa4e10d05824d hr-short  avia-builder-el-1  el_after_av_image  el_before_av_textblock  hr-center'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-mta0sf5d-765189f56f264305371184326d15a99f'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><h1 style=\"text-align: center;\">ASMA: Selecci\u00f3n de 10 art\u00edculos relevantes<br \/>\n(julio 2026)<\/h1>\n<\/div><\/section>\n<section  class='av_textblock_section av-mta0t4sz-ea9d38a8a3504e5e82a0ea2e57c7770f'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><h4>1. Gu\u00edas y nuevos conceptos<\/h4>\n<h3>GEMA 5.5. Gu\u00eda Espa\u00f1ola para el Manejo del Asma<\/h3>\n<p><strong>Referencia Vancouver:<br \/>\n<\/strong>GEMA 5.5. Gu\u00eda Espa\u00f1ola para el Manejo del Asma. Edici\u00f3n 2025.<br \/>\n<strong>Dise\u00f1o:<br \/>\n<\/strong>Gu\u00eda nacional multidisciplinar basada en evidencia.<br \/>\n<strong>Mensaje principal:<br \/>\n<\/strong>Actualiza el diagn\u00f3stico, tratamiento escalonado, biol\u00f3gicos, inflamaci\u00f3n T2 y medicina personalizada.<br \/>\n<strong>Relevancia cl\u00ednica:<br \/>\n<\/strong>Es la gu\u00eda de referencia para la pr\u00e1ctica cl\u00ednica en Espa\u00f1a y complementa a GINA.<br \/>\n<strong>Valoraci\u00f3n cr\u00edtica:<br \/>\n<\/strong>No es investigaci\u00f3n original, pero su impacto asistencial es extraordinario.<\/p>\n<h3>Clinical remission attainment, definitions, and correlates among patients with severe asthma treated with biologics: a systematic review and meta-analysis<\/h3>\n<p><strong>Referencia Vancouver:<br \/>\n<\/strong>Shackleford A, et al. Lancet Respir Med. 2025;13:117-130. doi:10.1016\/S2213-2600(24)00343-1. PMID:39549709.<br \/>\n<strong>Dise\u00f1o:<br \/>\n<\/strong>Revisi\u00f3n sistem\u00e1tica y metaan\u00e1lisis.<br \/>\n<strong>Mensaje principal:<br \/>\n<\/strong>Analiza las definiciones y frecuencia de remisi\u00f3n cl\u00ednica.<br \/>\n<strong>Relevancia cl\u00ednica:<br \/>\n<\/strong>Consolida la remisi\u00f3n como objetivo terap\u00e9utico.<br \/>\n<strong>Valoraci\u00f3n cr\u00edtica:<br \/>\n<\/strong>Existe elevada heterogeneidad entre definiciones.<\/p>\n<h4>2. Remodelado de la v\u00eda a\u00e9rea<\/h4>\n<h3>Mucus plugs correlate with small airway remodelling in asthma<\/h3>\n<p><strong>Referencia Vancouver:<br \/>\n<\/strong>Hsieh A, et al. Am J Respir Crit Care Med. 2025. PMID:40845271.<br \/>\n<strong>Dise\u00f1o:<br \/>\n<\/strong>Caso-control anatomopatol\u00f3gico.<br \/>\n<strong>Mensaje principal:<br \/>\n<\/strong>Relaciona tapones de moco y remodelado bronquiolar.<br \/>\n<strong>Relevancia cl\u00ednica:<br \/>\n<\/strong>Trabajo mecan\u00edstico clave.<br \/>\n<strong>Valoraci\u00f3n cr\u00edtica:<br \/>\n<\/strong>No demuestra causalidad.<\/p>\n<h3>Airway epithelial heterogeneity and mucus plugging in asthmatic bronchioles<\/h3>\n<p><strong>Referencia Vancouver:<br \/>\n<\/strong>Schworer SA, et al. Am J Respir Crit Care Med. 2025. PMID:40986379.<br \/>\n<strong>Dise\u00f1o:<br \/>\n<\/strong>Estudio traslacional.<br \/>\n<strong>Mensaje principal:<br \/>\n<\/strong>Describe proximalizaci\u00f3n epitelial y remodelado.<br \/>\n<strong>Relevancia cl\u00ednica:<br \/>\n<\/strong>Conecta inflamaci\u00f3n T2 y remodelado.<br \/>\n<strong>Valoraci\u00f3n cr\u00edtica:<br \/>\n<\/strong>Valor principalmente fisiopatol\u00f3gico.<\/p>\n<h4>3. Tapones de moco<\/h4>\n<h3>Mucus plug score predicts clinical and pulmonary function response to biologic therapy<\/h3>\n<p><strong>Referencia Vancouver:<br \/>\n<\/strong>G\u00f6tschke J, et al. J Allergy Clin Immunol Pract. 2025;13(5):1110-1122.e1. doi:10.1016\/j.jaip.2025.01.010. PMID:39826645.<br \/>\n<strong>Dise\u00f1o:<br \/>\n<\/strong>Observacional retrospectivo.<br \/>\n<strong>Mensaje principal:<br \/>\n<\/strong>El mucus plug score predice respuesta cl\u00ednica.<br \/>\n<strong>Relevancia cl\u00ednica:<br \/>\n<\/strong>Biomarcador radiol\u00f3gico prometedor.<br \/>\n<strong>Valoraci\u00f3n cr\u00edtica:<br \/>\n<\/strong>Precisa validaci\u00f3n prospectiva.<\/p>\n<h3>The pathobiology and treatment of mucus plugs in asthma and COPD<\/h3>\n<p><strong>Referencia Vancouver:<br \/>\n<\/strong>Fahy JV. Eur Respir J. 2026. Revisi\u00f3n de alto impacto.<br \/>\n<strong>Dise\u00f1o:<br \/>\n<\/strong>Revisi\u00f3n narrativa.<br \/>\n<strong>Mensaje principal:<br \/>\n<\/strong>Resume fisiopatolog\u00eda, imagen, biomarcadores e implicaciones terap\u00e9uticas de los tapones de moco.<br \/>\n<strong>Relevancia cl\u00ednica:<br \/>\n<\/strong>Art\u00edculo de referencia sobre el tema.<br \/>\n<strong>Valoraci\u00f3n cr\u00edtica:<br \/>\n<\/strong>No aporta datos originales, pero sintetiza el estado del arte.<\/p>\n<h4>4. Biomarcadores y fenotipos<\/h4>\n<h3>Phenotyping asthma and\/or COPD using 129Xe MRI and physiologic testing<\/h3>\n<p><strong>Referencia Vancouver:<br \/>\n<\/strong>Marshall H, et al. Am J Respir Crit Care Med. 2026;212(1):72-85. doi:10.1164\/rccm.202501-0288OC. PMID:41072430.<br \/>\n<strong>Dise\u00f1o:<br \/>\n<\/strong>Estudio transversal.<br \/>\n<strong>Mensaje principal:<br \/>\n<\/strong>Fenotipado avanzado mediante RM funcional.<br \/>\n<strong>Relevancia cl\u00ednica:<br \/>\n<\/strong>Medicina de precisi\u00f3n.<br \/>\n<strong>Valoraci\u00f3n cr\u00edtica:<br \/>\n<\/strong>Disponibilidad limitada.<\/p>\n<h3>INFORM ASTHMA: Budesonide-formoterol versus terbutaline<\/h3>\n<p><strong>Referencia Vancouver:<br \/>\n<\/strong>Noble JH, et al. Lancet Respir Med. 2026;14(2):151-162. doi:10.1016\/S2213-2600(25)00327-3. PMID:41520676.<br \/>\n<strong>Dise\u00f1o:<br \/>\n<\/strong>Ensayo fase 4.<br \/>\n<strong>Mensaje principal:<br \/>\n<\/strong>FeNO como biomarcador din\u00e1mico.<br \/>\n<strong>Relevancia cl\u00ednica:<br \/>\n<\/strong>Demuestra efecto antiinflamatorio.<br \/>\n<strong>Valoraci\u00f3n cr\u00edtica:<br \/>\n<\/strong>Desenlace principal fisiol\u00f3gico.<\/p>\n<h4>5. Manejo cl\u00ednico<\/h4>\n<h3>INFORM ASTHMA<\/h3>\n<p><strong>Referencia Vancouver:<br \/>\n<\/strong>Noble JH, et al. Lancet Respir Med. 2026;14(2):151-162. PMID:41520676.<br \/>\n<strong>Dise\u00f1o:<br \/>\n<\/strong>Ensayo cl\u00ednico.<br \/>\n<strong>Mensaje principal:<br \/>\n<\/strong>Consolida rescate con budesonida-formoterol.<br \/>\n<strong>Relevancia cl\u00ednica:<br \/>\n<\/strong>Cambio conceptual.<br \/>\n<strong>Valoraci\u00f3n cr\u00edtica:<br \/>\n<\/strong>Ser\u00eda sustituible si aparece un ensayo m\u00e1s influyente.<\/p>\n<h3>KALOS and LOGOS<\/h3>\n<p><strong>Referencia Vancouver:<br \/>\n<\/strong>Papi A, et al. Lancet Respir Med. 2026. PMID:41692019.<br \/>\n<strong>Dise\u00f1o:<br \/>\n<\/strong>Dos ensayos fase 3.<br \/>\n<strong>Mensaje principal:<br \/>\n<\/strong>Triple terapia inhalada.<br \/>\n<strong>Relevancia cl\u00ednica:<br \/>\n<\/strong>Alternativa antes de biol\u00f3gicos.<br \/>\n<strong>Valoraci\u00f3n cr\u00edtica:<br \/>\n<\/strong>Ensayo patrocinado.<\/p>\n<\/div><\/section>\n<div  class='hr av-3tsdlu-d567150b02b68644f2e4817842145048 hr-short  avia-builder-el-4  el_after_av_textblock  el_before_av_image  hr-center'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-1vmfyq-065dd78d39415aa035005bf2cd752d3e\">\n.avia-image-container.av-1vmfyq-065dd78d39415aa035005bf2cd752d3e .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-1vmfyq-065dd78d39415aa035005bf2cd752d3e av-styling- avia-align-center  avia-builder-el-5  el_after_av_hr  avia-builder-el-last '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img class='wp-image-1234 avia-img-lazy-loading-not-1234 avia_image' src='http:\/\/separcontenidos.es\/viaaerea\/wp-content\/uploads\/2026\/07\/Banners-web_02-2-2048x454.png' alt='' title='Banners web_02'  height=\"454\" width=\"2048\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[11],"tags":[],"_links":{"self":[{"href":"http:\/\/separcontenidos.es\/viaaerea\/wp-json\/wp\/v2\/posts\/1394"}],"collection":[{"href":"http:\/\/separcontenidos.es\/viaaerea\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/separcontenidos.es\/viaaerea\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/separcontenidos.es\/viaaerea\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/separcontenidos.es\/viaaerea\/wp-json\/wp\/v2\/comments?post=1394"}],"version-history":[{"count":5,"href":"http:\/\/separcontenidos.es\/viaaerea\/wp-json\/wp\/v2\/posts\/1394\/revisions"}],"predecessor-version":[{"id":1409,"href":"http:\/\/separcontenidos.es\/viaaerea\/wp-json\/wp\/v2\/posts\/1394\/revisions\/1409"}],"wp:attachment":[{"href":"http:\/\/separcontenidos.es\/viaaerea\/wp-json\/wp\/v2\/media?parent=1394"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/separcontenidos.es\/viaaerea\/wp-json\/wp\/v2\/categories?post=1394"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/separcontenidos.es\/viaaerea\/wp-json\/wp\/v2\/tags?post=1394"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}