METABOLOMICA Y ASMA
Resumen
El asma bronquial es una entidad de presentación clínica heterogénea, lo que probablemente corresponde a mecanismos biológicos parcialmente diferenciados. Tanto la descripción de dichos mecanismos como la búsqueda de un manejo clínico más diferenciado conllevan la necesidad de definir biomarcadores. Estos pueden ser de perfil convencional (p.ej. los eosinófilos) o derivados de análisis ómicos. La metabolómica estudia los procesos biológicos a través de sus metabolitos, productos intermedios o finales del metabolismo. A través de sus diversas técnicas y en muestras biológicas diversas se han estudiado los metabolitos característicos tanto del asma como de sus fenotipos. Destaca el papel jugado por los fosfolípidos, y las relaciones con el metabolismo de proteínas y ácidos nucleicos, la producción de energía y la inmunidad. Sin embargo, todavía faltan por definir perfiles metabolómicos claros y aclarar numerosos puntos de las vías metabólicas implicadas.
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